As part of the Signal-Seeker? product line, AAC04 acetyl-lysine affinity beads have been optimized to detect endogenous levels of lysine-acetylated proteins. Acetyl-lysine affinity beads comprise a proprietary mixture of two anti-acetyl lysine antibodies (Clones 7B5A1 and 10C4B2.1) that has been chemically conjugated to Protein G beads. Validation studies have shown that these beads can immunoprecipitate a wide range of lysine-acetylated proteins with minimal detectable leaching of either heavy or light chains in an IP assay. A comprehensive Signal-Seeker? acetyl-lysine Detection Kit is also available (BK163) and is recommended for first time users.