Product Uses

ARNO is a guanine exchange factor for Arf family proteins (1). It’s intracellular function is to regulate Arf proteins by transducing the upstream signal from phospholipids, kinases and Arf proteins themselves (2). Arno functions in large concerted cellular events that require re-organization of membranes e.g. cell migration (3,4), phagocytosis (5), macropinocytosis (6), and insulin controlled organism level growth (7).

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• Study inhibitors of ARNO GTP/GDP exchange activity

• Identification of ARNO Sec7 domain binding proteins

• Study of ARNO GEF activity with different GTPases

1. Chardin et al. 1996. Nature, 384, 481-484.
2. Stalder et al. 2011. JBC, 286 (5), 3873–3883.
3. Santy and Casanova. 2001. J. Cell Biol. 154, 599–610.
4. Viaud et al. 2007. PNAS, 104, 10370–10375.
5. Beemiller et al. 2006. PLoS Biol. 4, e162.
6. Cohen et al. 2007. MBC, 18, 2244–2253.
7. Fuss et al. 2006. Nature, 444, 945–948.