Product Uses

RasGRF1 is a guanine exchange factor with selectivity for H-, K-, N- and R-Ras, which mediates Ras isoform activation under a variety of conditions and has been associated with multiple diseases (reviewed in 1, 2).

• Study inhibitors of RasGRF GTP/GDP exchange activity

• Identification of RasGRF Cdc25 domain binding proteins

• Study of RasGRF GEF activity with different GTPases